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Patterns of Vitamin D Levels and Exposures in Active and Inactive Noninfectious Uveitis Patients

Mar 13, 2020

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  • To compare serum vitamin D levels and patterns of ultraviolet and dietary exposure between patients with active and inactive non-infectious uveitis, and population controls.


  • Prospective case-control study (n=151)


  • The median level of serum vitamin D in those with active uveitis (n=74) was 46 nmol/L (29, 70), significantly lower than the inactive control group (n=77) at 64nmol/L (52, 79; p<0.001). The active uveitis group also had lower median serum vitamin D levels than the local population median of 62nmol/L (IQR 46, 77).
  • Vitamin D supplementation was also significantly associated with uveitis inactivity (Kendall’s tau test, p=0.026).
  • In a sub-analysis of vitamin D deficient participants, sun exposure was significantly associated with uveitis inactivity (p=0.014 for weekday and weekend analyses).


  • Participants with active uveitis had significantly lower serum 25-hydroxyvitamin-D levels than inactive uveitis patients and local population-based estimates.
  • Vitamin D supplementation was found to be associated with decreased uveitis activity, as was sun exposure in those with vitamin D deficiency.
  • These results suggest that vitamin D supplementation should be studied as an option for the prevention of uveitis relapse in at-risk patients


  • Patients with uveitis completed a questionnaire on vitamin D exposure and underwent serum 25-hydroxyvitamin D measurement to investigate the effects of vitamin D levels on uveitis.
  • Results showed that patients with active uveitis had lower serum vitamin D levels than those with inactive uveitis and local population estimates.
  • Furthermore, in patients with low levels of vitamin D, increased sunlight exposure was associated with uveitis inactivity.
  • The authors suggest that these results support the association between vitamin D deficiency and autoimmune disorders.


Ophthalmology 2019 Jul 11;[EPub Ahead of Print]


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